Smart Reactors

Camouflage™ Technology

Camouflage™ Technology​

Camouflage™ technology is a proprietary coating technology incorporating a synthetic polymer combined with a proteinaceous base layer. The coating technology is non-toxic, demonstrates excellent hemocompatibility, and endotheliazation.  It is designed to reduce clotting cascade initiation and provides long term stability for use on a range of blood contacting medical devices. Camouflage™ is underpinned by solid Intellectual property (IP) to differentiate and to create value for our customers. ​

Camouflage™ is a passive (non-heparin) Biocompatible coating which utilizes a gentle water-based chemistry, It adheres to all medical grade material without the need for UV or thermal crosslinking. By design, the “mechanism of action” provides for a cloaking effect on the device surface to mask from the circulating blood. Camouflage™ is your only choice for a smooth pathway to regulatory approval.

Camouflage™ is a high performance Biocompatible coating technology with long-term stability & durability performance on blood contacting devices. The problems we solve include;

In the world of medical implants, hemocompatibility is not just a requirement—it’s a necessity. Devices that come into contact with blood must function seamlessly, without triggering complications like clotting, inflammation, or immune responses.
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The integration of surface coatings, such as Camouflage™, aims to mitigate these complications by enhancing both hemocompatibility and endothelialization, allowing for smoother recovery and better device integration.
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In medical device manufacturing, preventing infection is as critical as enhancing functionality. Devices that interact with the body, especially in sensitive areas like surgical implants or blood-contacting surfaces, are at constant risk of bacterial colonization, which can lead to severe infections.
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Mechanism of Action​

Camouflage™ acts by retaining a layer of the patient’s non-inflammatory proteins (red blood cells and blood components) on the coating. This hemocompatible coating masks the device surface from the circulating blood, reducing the body’s reaction to the foreign material. It also promotes endothelization, supporting the attachment of endothelial cells for long-term biocompatibility. Additionally, the antimicrobial properties of the coating help prevent infection, ensuring a safer and more durable implant.

Benefits of Camouflage™

Excellent Performance

Camouflage™ coating technology demonstrates superior hemocompatible and promotes endotheliasation.

Adheres to many Substrates​

Camouflage™ coating is a versatile coating that adheres to many substrates.​

Ultra-Thin Coating

Camouflage™ coating is a superior thin coating, colourless to the naked eye.

Long Term Durability

Camouflage™ coating demonstrates longer term durability on a range of devices.

Non-Medicinal and Heparin Free

Camouflage™ coating technology is a non-medicinal solution.

Lean Manufacturing Process

Camouflage™ coating technology is easy to integrate into manufacturing process.

Choose Superior Coating.
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Camouflage™ Hemcompatibility Testing Results

Camouflage™ is designed to reduce Thromboembolic conditions while promoting cell proliferation. Our Research & Development team has conducted a series of hemocompatibility tests, comparing Camouflage™ to both phosphorylcholine and albumin coatings. The results demonstrate superior performance across key coagulation pathways as shown below in figures 1, 2 & 3.

Testing conducted in Chandler Loop Model per ISO10993-4(centre)

Excellent Performance

Camouflage™ Coating has been tested  for biocompatibility requirements. Reference table 1  below;

Fig 1, 2 & 3 below shows a SEM analysis of a PVC substrate coated with PC-1059 PC, SR (Camouflage) and an uncoated control. These samples were incubated for 60 minutes in lightly heparanized human blood, rinsed with saline, and fixed for microscopy.

The uncoated control had a significant buildup of erythrocytes, with a fibrin network visible indicating rapid progression towards Clot. The camouflage™-coated surface was devoid of fibrin, and the adhered platelets did not show morphological changes suggestive of activation. The PC coating did not show a fibrin network; however, there were leukocytes attached to the surface, indicative of an immune system recognition of the surface.  

Fig 4 and fig 5 demonstrates the viability of cells on coated and uncoated Nitinol stents after 1hr semi-dynamic incubation and after 29hr static incubation. 

Endothelialization- Cell viability

Figure 6 shows the viability of cells on coated and uncoated NiTi stents after 1hr semi-dynamic incubation and after 29hr static incubation.  

Biocidal Properties- Contact & Recovery

Evaluation according ti USP<1072> Disinfectant and Antiseptics. 1Hr. contact with coating and evaluation of reduction of culture counts vs controls.  The biocidal properties were evaluated in reference to fig 7. 

  • 2.1 log (99%) reduction in E. coli
  • 2.5 log (99.7%) reduction in P. aeruginosa
  • 1.7 log (97.7%) reduction in C. albicans
  • 0.7 log (80%) reduction in A. brasilinensis
  • 0.6 log (73.5%) reduction in S. aureus
  • 0.2 log (49.6%) reduction in B. subtilis
Fig 7

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Adheres to many substrates

Camouflage™ coating is versatile and adheres to many substrates without the need for specialist pretreatment. The coating can be applied as either a dip coating or in flow to coat all substrate geometries without the need for UV or thermal crosslinking.
 
Camouflage™ coating is versatile with most polymeric and metallic substrates, including, but not limited to, the items listed below.

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Ultra-Thin Coating

Camouflage™ coating is just a few nanometres thick and is suitable for a broad range of application within the medical device space. ​

This ultra-thin coating does not impede gas exchange permeability on perfusion devices and is custom developed to avoid thrombus formation and promotes endothelialisation of surfaces for long term implants.

Thermoplastic​ (701 x 488 px)-2

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Long Term Durability

Camouflage™ has a crosslinking chemistry which ensures that the coating matrix is durable for long term applications with covalent bonds providing stability. This crosslinking chemistry is performed in water and does not rely on Ultra-Violet light or on heat. This allows us to apply a durable coating on samples with complex geometries where UV light can’t reach and where thermal stability is a concern.

28d stability study on PVC tubing- 37 Degrees Ce in saline in-flow to simulate physiological shear stresses using a Chandler Blood Loop method. Samples remained  coated, with 100% uniformity of coverage supporting applications such as ECMO.

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Non-Medicinal Polymer (Heparin Free)

Camouflage™ coating technology does not incorporate active pharmaceutical ingredients. It is designed to control the interaction of the surface with the​ circulating blood, while retaining non-inflammatory proteins and blood constituents​ on the surface. With real surface passivation Camouflage™ does not rely on pharmaceutical​ mechanism of action, however, demonstrating ample performance when compared to heparin in terms of thrombus reduction.​

Camouflage Heparin free technology simplifies the supply chain for manufacturers and provides the least path of resistance to regulatory approval. The technology is not considered a​ combi-product and does not fall under Rule 14 of MDR. 

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Manufacturing Process

Lean Manufacturing Process

  • Camouflage™ coating technology utilizes a lean manufacturing process which can be transferred into your new or existing facility with ease
  • It utilizes a water-based process with no hazardous organic solvents.
  • The process can be a dip or flow through process, which services the majority of applications
  • The crosslinking process does not require UV or Thermal curing
  • There is a minimal Capex requirement to get you up and running (<€100,000)
  • Our technical transfer program provides all the necessary specifications to allow for a complete set-up of the coating process and operative training at your facility.

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